NMR line shapes and multi-state binding equilibria
نویسندگان
چکیده
منابع مشابه
NMR line shapes and multi-state binding equilibria.
Biological function of proteins relies on conformational transitions and binding of specific ligands. Protein-ligand interactions are thermodynamically and kinetically coupled to conformational changes in protein structures as conceptualized by the models of pre-existing equilibria and induced fit. NMR spectroscopy is particularly sensitive to complex ligand-binding modes-NMR line-shape analysi...
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ژورنال
عنوان ژورنال: Journal of Biomolecular NMR
سال: 2012
ISSN: 0925-2738,1573-5001
DOI: 10.1007/s10858-012-9636-3